◆ SpookStack

•- .-So** >- C^; faSV’hs «" mm They shoved changes similar to those in Group V, but the changes vers slightly nous pronounced. Be rtnon for thls^ is our opinion, is tint tho prooulot Inhibited pain sad irritation Aron the alanine in the local tissues, and t-*— did aot provoke such « pronounced cortical, response in the adrenals* In Other words, there was less stress phcnoBsnon.provokod in tho adrenal# Group YU consisted' ot 6 rets, receiving 0*1. mg* of alanine daily, pies 1 gg* dsia^ of Cortisone. These rata ware sacriflcsd on the26th day* No significant change was observed in my organ* The cortisone had completely inhibited the response to elsmine* Conclusion . '! It nay be conceded from the above experiments and observations that | a diaaino bensene derivative, which we have tamed alanine, is a relatively specific irritant amine, vhleh is capable of hydrolysing the ceoent and ground j Ubatancea of connective tissue and of producing the so-called collagen diseases. At the sane tine it provokes the general adaptation syndrome, but if given in sufficient amounts or concentration it is capable of overriding the *• . ..... ..... .. \ .... protective response of the general adaptation syndroms, which it provokes* This irritant aaine can be neutralised in its pathologic affects by tte simultaneous ^ aAniniatration of sufficient anounta of cortisone* Tbs collagen diseases which we believe to be reproducible with sub- stance are: rheumatic carditis, rheumatoid arthritis, scleroderma and dermato- ngrositis, and polyarteritis. In the experiments recorded above glomerulonephritis and meabraneoua gleaerulitis with wire-looping in the capillary loops cf the nephron characteristic of disseminated lupus erythematosus were not observed* Since this J is undoubtedly a collagen disease, an attempt to produce such changes was in a final group of experisenta* Six Wisfcar Bale rats, weighing 60 to 60 On., were painted daily with a 2 per cent solution cf alannino to a shaved area of the thigh 2 x 3 cm* The smaller rats were chosen in preference to raising the WAftNlMO HCfflgg • *