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DOC 0000017443
Page 366
366 / 419
alanine dosagt.
These rats died after three daps and c caplets autopsies were
performed.
They showed changes in the heart and Joints characteristic of early
xheonttlo carditis and rhsuuatold arthritis,«s:;jreTionsly described*
la addition
all of tb rats showed aoabraasoqs- ^teawulcBaphrttta^ with wire-loops character-
istic of disseminated lupus ciythcaatosus.
There were alsoTSScolar lesion* in
the train, sach as are seen In collagen diseases, and saall focal accuawlatlonc
of glttcr cells, resembling typhus nodules, a reaction to raceular damage*
The
type of collagen disease observed, therefore, is dependent upon the concentration
of alaxaine released in the tissues*
\jvn”TW
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