◆ SpookStack

. . . _•„ . ...— ; ... _ ... . • . ..-'-J ,,, .. -. ...... 1 ... , . J.. I jjj. 1 ... -,,1 ' -.r.tIr-y4-jgrt J" ' - V- * :.f ~£m r ;; .- - *. * - _ - - ‘ ; . 7Z amlnas, which we have termed alanlnee, neutralise adrenalcortical hormone# in tbs tissues and tins release AC1B and stimulate tbs general adaptation jgm» ! drome. They are in turn neutralised by increased excretion of adrenal cortical ^ bomcmt if bodily resistance is adecpoter (the resistance phase of Selye)* Beneever, if tissue dosage is overwhelming the body passes rapidly through the phases of dam and resistance to exhaustion* Such acute exhaustion is synonymous with Irreversible shook or peripheral vascular failure (so-called forward cardiac failure)* IT overwhelming acute stress involves the ianma mechanism, the high concentration of uansutralised alanalne prcvctoc the ; Arthus’s phenomenon with its characteristic vascular thrcobocis and resultant tissue necrosis* If stress is mxiuiyprQlOT^ exposure to infections or siallar antigens, the continued and increasing release of tmneutralised alaimina exhausts the adrenals or exceeds their protective capacity (even In the presence of cortical hypertrophy), and collagen disease results* Bis Stress As of Alazcdne In the experiments reported above tbs adrenal ccrtisdL enlargement observed nay be considered an indirect effect of ale-mine, which neutralises cortisone —-* in tbs tissues and thus stimulates tbs adenorypephyeia, which releosos ACTH _ '**’* .»• to bring about tbs cortical hyperplasia. Another interpretation* however, is possible. The alanine nay act directly on the adrenal medulla, which in - - V. turn releases adrenalin to stimulate the adenohypophysis to secrete increased £ ACTR* This second interpretation is suggested by the degenerative changes in the adrenal medulla, which were observed, in a- further group of experiments described below. Whether either or both Mechanises apply, the fact remains the adrenals under- go enlargement !in some animals to four times their normal weight)* The changes * In the lymphoid tissue, particularly majjred in the spleen, are the result <f - the adrenal cortical hyperplasia* The alanaino in any event initiates the adaptation syndrome*