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DOC 0000017443
Page 364
364 / 419
la order to demonstrate tho relationship joS alanine to cortisone and to
tbo stress phenomenon, which Sclye baa termed tbs general adaptation ayndraae,
.
a third group of experiment* mas performed*
Thaxata need sera males at the
Uatar strain* neighing 200 bn* each* and- were injected intramuscularly six
daje woekly for 2
$
days and than aacrifiead.
The tisanes of ell major orgaas
sere examined*
.
Group Z consisted of six control rats* receiving 2/2 cc* of normal saline*
So significant changes verw observed in this group*
One m1mi1 had murine
~
pneumonitis, and one had sons Increase In the connective tissue calls betseen
the myocardial fibers*
Group u consisted of 6 rata, receiving 0*1 cc* each of spirits of tur-
pentine*
These rata sure sacrificed, on tha ninth day*
They shored mild
perivascular edema and separation of connective tissue fibers about
1
vessels* but none of the striking changes observed with alanine*
There was
mr a±renal hypertrophy.
Group XXI consisted of 6 rats, receiving 1~ mg* daily of an
compound
in which methyl piperasine was linked with propanol to dimethyl piperaslns*
Ho
eignificaat changes were observed in these rate, when sacrificed on the 26th day
Group ZV consisted of 6 rata, receiving 2*5 mg* daily of an anlne epapound.
In which nethyl piperidine was linked with another molecule of piperidine by
propanol*
Ho significant changes were observed in these rats when sacrificed on
the 26th dgjr*
Group 7 consisted of 6 rata , receiving 0*1 mg* daily of alarodne*
These
rata were sacrificed on the 26th day*
They showed changes in the lungs* heart*
joints* spleen and adrenals similar to those repotted above in the rats painted
with 0.5 per cent solution cf alarmine in sesame oil*
Group VI consisted of 6 rats, receiving 0*1 mg* of alarmine daily* plus
2.5 mg, daily of procaine E01* These rats were sacrificed on the 26th day.
^TiTIT
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