◆ SpookStack

riMOAteld aad eolltga that w are dlteuilai it « dtpoljairliattoB of with leakage and hydration of the ground' anbetanee with NMainy less of collagen fibrils* _laut**poaoe. to the hydration of tha ground ad) tht cooatctlfB tissue cells prolifcrate and enddbvta to the ladioff Vodlei. (which at first costala only liberated endothelial ealla fro* destroyed eapll- larle*} aad fora rfceanatold nodulse, -which art so eharacteristio of tbo rheunatold state* Slace the baseoeat nenbrane U the prlnarlly affected structure aad. this la composed of condensed ground substance aad retieulla fibers aad sot of the aore highly differentiated collagen fibers, the tar* eoL» lags* disease does net describe the prinavy process* The flhrlaoid degeneration otwmd la a eoagolu* of the ground substance aad it substance* the endothelial aggregates*, which previously have been neglected, arsrprevided by separation, of the endothelial eells fro* altered or dissolved capillaries. a*dotfc*li*l proliferation and fibroeytlc proliferation both contribute to the formation of the Aschoff body aad are both secondary to the freeing of these fined cells which cons to lie free in a fluid natrlx* vbloh is aoetly blood plasna and partly hydrated ceaent substance aad natrix* Shore is good reason to bolieve that the general adaptation syndrone of Ssiye , in vhich the adrenal caftex plays the dominant role, serves as a co-defensive nechanisxt both in local tieene dosage and In the inomnologicel responses of the reticuloendothelial spates » Sayers* believes that products of tissue damage following severe injury combine with cortical homonos in the peripheral tissues, and with the resultant fall in their concentration in the venous blood* this noraal chech on the adenohypophysis is released and the pituitary responds by increased secretion of ACTS* This resultant Increase in the output of ACTS depletes the adrenal cortex of its horaonae and stimulates additional homone production.