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5 - Toxic Delirium, Before the days of penicillin, and die antibiotics, disorienta- tion and fteifyiirm were frequent complications of severe infection. It was common. In pneumonia, and treated by forcing fluids either intravenously or by mouth. However, the toxic effects on the central nervous system of common infectious organisms received no detailed study* Jo garyyrftl, the cause ofthe delirium was related to the severity of the Infection. In sununarizing the known facts about uremia, hepatic coma, eclampsia and toxic delirium we can say that the specific cause of the cerebral depression remains unknown in all of them. The only common pathologic effect is the lowering of the cerebral uptake of oxygen. This, however, apparently is a consequence of the suppression of cerebral function rather - than a causative factor. ’ > 6 - Cerebral Toxicity Associated with Poisoning. The terminal stage of most forms of poisoning is usually described as ''Convulsions, coma and death". The localization of the underlying cerebral effects, however, has not been ascertained for the systemic poisons. In an attempt to arrive at a compendium of present day information we have summarized the pathology of various forms of poisoning in the tabulations, submitted with this proposal. Plan of Procedure - Analysis of Body Fluids. We propose to establish a laboratory for the chemical analysis of body fluids in the toxic cerebral states. When patients with toxic cerebral mani- festations are under observation in the hospital for uremia, hepatic coma, eclampsia, malignant cachexia, etc., blood serum, cerebrospinal fluid, intraperitoneal fluid and pleural fluid will be obtained and fractionated for possible toxic components such as phenol, bile acids, toxic amines and other components that may be found of interest as the project develops. This * analytical laboratory will employ two biochemists. One will be associated with the routine service laboratories will supervise the collection and_ 0