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Fdbruac3cl95S - 1957 _____ * "".Parti ' Bio-assay and Chemical Analysis of Body Fluids in Toxic Cerebral States . General Survey of the Problem • There are a variety of clinical conditions, many of them terminal, in which patients under clinical observation, pass front mild disorientation into delirium and coma. These con- ditions of cerebral intoxication, are often associated with the failure of some vital organ other than the brain. The most important forms of such cerebral intoxlcationa are m 1 - Uremic coma associated with renal failure 2 - Hepatic coma associated with liver failure 3 - Convulsions and coma of eclampsia associated with the pathology _ of the placenta and Involving also the liver and kidneys 4 - Malignant cachexia associated with advanced carcinomatosis 5 - Toxic delirium associated with severe bacterial infection, at times with a generalized septicemia or bacteremia 6 - Delirium, coma and convulsions resulting from chemical poisoning in which the toxic substanceumay act directly or indirectly on cerebral tissue. 1 - Premia. A review of the current texts and contributions to medical journals reveals a remarkable lack of information concerning these forma of cerebral intoxiaatioiu; ! Thus, in uremia there is a wide difference of opinion in regard to the identity of the urinary constituents retained in the blood which are responsible for the effects on the central nervous system. Fishberg states that after a hundred years of search for the "uremic principle" its identity still remains a mystery. Homer Smith, in his work on the kidney, stresses the importance of potassium retention. Others have implicated the magnesium ion. Most authors