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(b) Can we improve our methods of signal production, possibly by using a multiplicity of voices, with the purpose of capitalizing upon the force of group decision and suggestion. > i (c ) Can we develop better methods of inactivating the patient during the period of driving (exposure to repetition), and at the same time maintain him at a hitter level of activity, by physiological and chemical agents, than by the present physical effects. Among the chemical agents which we_ propose to explore with respect to their capacity to produce inactivation are the following (used either singly or in combination) :*• Artane Anectins ... Bulbocapnine Curare t • We propose to use LSD 25 and other similar agents as a means of breaking down the ongoing patterns of. behavior.^ Second Objective: Among the other physiological functions "which we intend to explore with regard to their amenability to change in consequence of the repetition of verbal signals are: palmar skin conductance skin temperature he a 1 ing offwou nd s Procedure to be followed : The initial procedure which we propose to employ is that already outlined under section D. From the context, however, it will be clear that we hope to be able to modify and improve the procedure as we proceed. . The patients selected are almost entirely those suffering from extremely long-term and intractable psychoneurotic conditions. In the case of results of physiological driving, the validity of the findings can be assessed by statistical analysis. Repeated estimations of the particular physiological, function are made prior to driving and at various _ periods subsequent to driving (exposure to repetition). In the case of the studies upon the effects upon behavior of exposure to- repetition of verbal signals,