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RESEARCH IEEDPOSAL 1955 - 1956 Three llnes^f biochemical investigation are proposed for 1955. These are being pursued with -Senior consultant, and the. compounds areyeing p. id, as in 1954, by ^at the t The chief interest in work for 1955 will be in the thiol compounds, some of which have carboxy groups, as well as omiTia groups, and some ofj$hieh have either curare or soporic action. ^will continue his work on the dlphenolic compounds. In fids work the nitrogen for the first time will be placed directly on the ring. A wide variety of biological effects is found in these compounds. The work of /c7 twill center about the hydrogenated quinolines and the indole alkaloids. Not only will the propanol linkage be used in the synthesis of these new compounds but also the methyl propanol linkage and a linkage in which the carboxy group substitutes for the hydrojtyl in the propanol. Biological testing of these compounds will be more elaborate previously and the assay technics will he broadened to include Work on the tracheal rings of the guinea pig, hyperthermia in rabbits, blood pressure and cardiovascular effects and anticarcinogenic effects.