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i DRAFT 21 March 195f MEMORANDUM FOR: THE RECORD #>/ SUBJECT Frojec-t~MKULTRA , Subproject 45. 1. The scope of this project is intended to encompass all those activities now engaged in by the in its own facilities tinder the direction of TSS, Chemical Division. These activities will take the form of three lines of biochemical investigation? namely, the curare-like effect of certain- thiols, the prepara- tion of hydrogenated quinolines and indole alkaloids, and the continued study of diphenolic compounds. In addition to the above investigations, the present biological testing and as- saying techniques will be elaborated and broadened to include cardiovascular and anticarcinogenic effects of compounds re- sulting from the above programs. ((*7) 2. The attached proposal from s the extent of the investigations that his facilities will allow him to carry out on the materials developed in the three lines of research referred to in paragraph 1. as well as certain other materials of interest to TSS/CD. also serves ( as a general consultant to this Division and provides cover and' cut-out facilities to the Agency. 3. The total cost of this project for a period of one year will not exceed $100, 000.(30. At the present time, the sum of $40,000,00 is being committed, the balance of the total to.be committed at a later date. . —^ 4. been granted a TOP SECRET clearance by the Agency, and is fully capable of protecting the security of the Government's interest in this matter. APPROVED FOR OBLIGATION OF FUNDS: TSS, Chemical Division APPROVED; L&-V- ; : Research Director Date: 4 Attachments: Proposal Original Only. < ief, TSS/Chemical Division • APPROVED FOR AIDITIONAL APPROPRIATION CV 127,000s