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and oral administration without the presence of the methionium. group. These compounds (in suitable doses) have been used in a series of over 50 patients by both. Intramuscular and oral routes. At the low dosage level usecHhey shewed specific muscular relaxing effects on selective organs; some of them relax voluntary muscle while others show specific relaxing effect on the musculature of either the urinary tract or the gastrointestinal tract. The voluntary muscle relaxants have been used on patients with paralysis agitans and rheumatoid arthritis. Those which relax the smooth muscle of visceral organs have been used on patients with, disturbed bladder function, with multiple sclerosis and prostatic hypertrophy. has continued to cooperate under a written agreement (previously arrived at) in synthesizing starting materials for quinolines for, They have supplied hydrogenated and nitrated some of the diphenolic compounds in cooperation with It is proposed to continue this cooperation. WARNING N