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SUB-PROJECT NO. 68 PRINCIPAL -RESEARCHER AND LOCATION ; Or. D. Ewen Cameron Allan Memorial Institute of Psychiatry at McGill University Montreal, Quebec OBJECTIVE AVO OETAILS OF WORE, : To study the effect coon huran be- havior of the repetition of verbal signals. .This worl< resulted fro.t a request to the Society for the Investigation of Human Ecology from the Allan Memorial Institute of Psychiatry for a grant: "to study the effects upon human behavior of the repetition of verbal signals". There is no evidence that the Agency influenced the nature of this research. Patients selected were those suffering _ from extremely long-term and intractable psychoneurotic conditions. They were treated with LSD-25 and other similar agents to break 1 down on-going patterns of behavior. The plan included intensive re- petition (15 hours a day for six or seven days) of prearranged ver- bal signals — patient is kept in partial sensory isolation -- then continuous sleep for seven to ten days. Lasting behavioral changes of two months duration were achieved in one case. 23 April 1959 Memorandum for the Record states that Dr. Cameron completed over 100 cases, "with some rather dramatic results, parti cularly with neurotics". there is no indication in the rile as to whether the patients were witting.