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c SUB-PROJECT NO, 44 PRINCIPAL -RESEARCHER AND LOCATION : Universi ty of II] inoi s College of Medicine, Chicago OBJECTIVE AND DETAILS OF WORK : The objective of this research was to develop screening and bio-assay techniques for psychomi- metic (capable of proudcing a psychotic-! ike state) agents which do not involve human testing. The work was not classified. APPROXIMATE TIME SPAN : 1956 - 1958 SIGNIFICANT ASPECTS : Although this research was confined to the use of small animals, the last paragraph of the proposal states: "In the course of the work this year we have tested a number of -compounds of a completely different chemical nature from the known psychomimetic agents. The animal tests indicate that these com- pounds may be psychomimetic in man. During the coming year we propose to complete the work on the screening techniques so far developed and put them on a basis that will make them useful as routine laboratory test procedures. Also, we shall continue work with the new agents, carrying them to human test to verify their psychomimetic activity." There is no indication that testing on human beings occurred. FUNDING : COVER MECHANISM : Geschickter Foundation for Medical Research APPRQXIMAiE TOiAL : 343,000 - Sterile checks made to the University 133