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C ' , C* v v MfcWStSgJ RESEARCH PROJECT APPLICATION The testing in animals and human volunteers of chemicals and bio- chemicals which alter behavior. .-- r PLACE; The New Jersey Neuro-Psychiatric Institute The Bureau of Research in Neurology and Psychiatry Princeton, Mew Jersey (P. 0. Box 1,000) . PRINCIPAL INVESTIGATOR; Car l C. Pfeiffer, Ph.D., H.O. .GRANI AON IN I S T PAT ORS^ New Jers ey Men tal Hea l th Res ea rch and Development Fund, Inc. I Jilt Lane, Trenton 8, New Jersey Henry P. David, Ph.D., Secretary-Treasurer 3 * INTRODUCTION: The «3gg%j%gg£ggg^i has aide d the research studies of the principal q i iA.ii M.uyio gf tne principal investigator for more than ten years, during which time many notable advances have been accompl ished. 1 £ At present the supports the search for newyKal luci nogens (chemically simpler than LSD~Z5) . These are synthesized by-^^S^ tested in animals and in JdlJLES systems and then cautiously tested in man. is taking a leave Of absence ne xt^jf ear end will work in 195T as head of medicinal chemistry in the His synthetic work wi II continue in 1961, and in ISi0-JS6l we wiif test the backlog of compounds already synthesized. The grant to Emory will terminate as of Hay.31, I9S0, which is the close of the presen t grant year . Other funds are available at Emory to continue the testing of t he ^^^^co.r'pounds at the Atlanta federal Penitentiary under the direction of H.D. from the period June 1, to December 31, I960. By this. time the human testing will be organized and progressing in New Jersey under the direction of the principal investigator. On July!, 196 1 40SSB&$g**f^- wj | j j£ have completed his. last six months of a split internship and will join the research team in the New Jersey location. SENSITIVE >JRCES AND RESEARCH PROPOSALS; A. Pharmacological testing in animals of candidate hallucinogenic chemicals. B. Study-of simple compounds which may inhibit trained behavior such as the conditioned avoidance response. .* C. Careful study of compounds in normal human'volunteers for possible behavioral changes: . 1) «^||5!8^synthesized compounds 2) Compounds supplied by B 3) Biochemicals purchased NOTICE ENCE OLVEO