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.•*J* *?.**f * 't, f »•* '**j»»* t* •• • * * *• i# .»»•? •«•; T'-i . r : 7? - >© proposal SUBJECT- The Testing In Animats and Unman Volunteers of Chemfcals —^ and Btochcmlcals Which Alter Behavior. . & rp. The New Jersey Neuro-Psychiatric Institute PL-ACF- The Bureau ol Kesearch in Nenrology and Psychiatry Princeton, New Jersey (P.O. Box 1, 00D) PRINCIPAL INVESTIGATOR: Cart C . Pfeiffer . Ph.D.. M.D. r^r AnMTMSTRATORS: New Jersey Mental Health Research and —— - Development bund, Inc. f=j 1\ 1 Lane. Trenton 3. New Jersey^ Henry^P. David. Ph.D., Secretary-Treasurer 1. is proposed ...ondncd sereeMng^nd ™ Motoglealty net.ve ecnpour.ds to deter- mine their action on the central nervous system of man. addition to these Investigations, the following work will be undertaken! 1. Pharmacological testing will be conducted nn animals utilizing candidate hallucinogenic chemtcjUs. ' 2 Studies will be conducted on compounds of relatlvly ! sim!t'e cln guration to assess their abtlUy to Inhibit trained | . ulhavtor In animals utlllalng the condition avoidance responses. • 3 Studies will be conducted of compounds In normal human - volunteer s^for possible behavioral changes u, Hiring compounds | provided by the sponsor. i 1. Quantitative studies of the KEG in animats and man to : determine stimulant or depressant effects of candidate mater lats.