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- . v- .\: -ia’rwji’ ^vtab'Jir vsSv*/ .•*.'tX v ..srtWW* and Pfeiffer, C.C. Use of normal subjects for testing drugs (Upjohn Conference), Clin. Pharmacol & Therap. At the Federation meetings in ft, this month. will report on,* -» C - , „ and and Pfeiffer will report on. Quantitative electroencephalographic analysis of the ef fects of lysergic acid diethylamide (LSD-25 and d-amphetamine in ma n . At*wgg^aaaa^eaitfB^ and in Munich Dr. Pfeiffer is giving a paper on, Further Quantitative electroencephalo- graphic studies: of the stimulant effects of deanol and d-amphetamine in man. ^ - - • • Abstracts of these four papers are enclosed. In addition to the above, which are ready for formal presentation, the following are under way: A number of tryptamine derivatives are being explored for psychotomimetic and other effects; 4-hydroxy-a-methyl tryptamine, 4-methyl-a-methyl tryptamine, 6 -hydroxy-N,N-di methyltryptamine (The di-methyl analogue of Szara's compound), px'olyltryptamine, psylocin, and acetyl tryptamine. Results will be reported ^as^T:hey accrue. The central actions of ^-aminobutyric acid are being indirectly explored by investigating y-butyrolaetone and y-hydroxybutyric acid. Unlike GABA, these compounds readily cross the blood-brain barrier, and the:latter is a potent hypnotic agent and about as active and positive as is chloral hydrate. 1 has rmnrl-f»d an ahnnrir.al FPC Mtnmca has reported an abnormal EEG response to intravenous thiobarbiturate in schizophrenic's. Our quantitative method shows no difference as yet in response between normals and schizophrenics, to the intravenous injection of thiopental. S0URCEsV6 MrfTHprfs Ih’VOLVEa-