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DOC 0000017443
Page 370
370 / 419
-
;
• -c
-
"
.
2. Code:
Ax7
This synthetic work relates to compounds of the structure
• A
-—~
.
3-
&H-CH*
-
*
m/
\t-CH2CHOHCH2 -B
ch2ch
*>
their acid addition salts and quaternary ammonium salts,
'
•
*
and the formyl derivatives,
HCOnC
/tt-CH2CHOHCH2-B
C^gH
:
'•
-
which may be used in the synthesis of I
where A is a member chosen from the group made up of H and cw^
and. B is a monovalent amino radical which is a member taken from
the grotg) made up of the following:
(1) a radical of the structure RNH- where R is
an alkyl radical from 1 to 4 carbons
n*
(2) a radical of the structure -N
where K
r and B cr are alkyl radicals, the total carbon content of which is between 2 and
-
8
(3) a heteocyclic radical which is a member of the group made up of
pyrrolidino, piperidino and morpholino
(4) 1-(1, 2, 3 , 4-tetrahydroquinolino), l-(decahydroquinolino).
1-
(6-methoxy-l, 2, 3, 4-tetrahydroquinolino) and
2-
(l, 2, 3 , 4-tetrahydroisoquinolino).
Typical compounds: CH3NHCH2CHOHCH2^
H2C^NH
nch 2ch2
HjjOH^N_0% CHOHCH2N(^a9 »a
^-CHaCHOaCHs-iO^
CH2C^
rtmnw.
^
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