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DOC 0000017443
Page 349
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qrcnffMtnHjyn of the fluid to be exchanged which may alter diffusion constants by its ionic
ar osmotic components, or alter the diffusion rate by containing constituents which damage
or otherwise alter the diffusion membrane .
'The second factor is the biological
of the ««ffmrfrvn membrane with its living structure and collagenous matrix.
In the past
several hundred years the tanning industry has been working with the biochemical
properties of collagen since leather is 90 to 95% collagen,
lie workers in this industry
have accumulated a large amount of information on two different agents.
Those 'that wet
or render more pliable collagen matrix and therefore make it more porous, and those
that harden or toughen the collagen matrix and therefore render it less permeable.
The
class of sgwrtg is termed lyotropic and its classical member is dilute acetic acid.
The other group of agents is called tannin and the classical agent is tannic acid or the
pyrogallic acids.
This group of agents can be applied to the diffusion membranes to alter
their reaction.
Since many of die induced cerebral states can be attributed directly to
hydration or dehydration of the cerebral substance, this investigation of the diffusion rates
Wr> and out of the serous cavities of the meninges offers a fundamental approach to study
of <me aspect of cerebral function.
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