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lliitii i 'dV- »« . PROPOSED RESEARCH PROGRAM & - Four lines of investigation are proposed for the year 1957-58. The first line of Investigation is the continuation ofthe toxic psychic states asillustiated by uremia, which was began under the last grant. In the present proposal it is planned to stmfy various phaaoa of the uremic state along two major lines. One of these is the biochemical and pathological investigation, of patients admitted The other line of investigation will be pursued on experimental animals. Kidneys have either been removed or have been rendered nonfunctional by the ligation of the ureters. The major aspects of these two investigations are discussed in the appended report. continuation of the investigations o • **~'*»D*thw , Th e fleermd investigation, proposed has to do with the investigation of novel glucose metabolic blocking agents. We are currently investigating a series of diglycolate derivatives which we have shown to block glucose metabolism with resulting storage of glycogen in tbe various, organs, liver and kidney. The details of tills are also appended. The third proposal has to do with the study of some cyclic diaznino compounds which we have shown produce the stress ofphenomonen and associated rheumatoid states. The details of this proposal are also appended. — - The fourth proposal' concerns the continuation of chemical synthesis of a variety of piperazine compounds whif h will be linked with sarcosine. This report is also appended. A similar line of chemical synthesis is also being carried out on nitrogen-containing bis phenols. These two parallel lines of chemical synthesis are a