◆ SpookStack

E3 I2CD2I; CL BY a87475 21 January 1958 MEMQRAKDDM FOR: THE HBCCHff SUBJECT • Continuation of MKULERA, Subproject No* 45 . 1. The scope of this subproject Includes all t]to3^^ctlvltl.e3 now engaged In by'4MHMNI under the direction of TSS/CB with the exception of those cutout » functions specifically mentioned in connection, with other MKUJLTRA subprojects . Xn general, the research effort under this subproject will continue along the lines laid down- In previous years. These Involve the synthesis and pharmacological and clinical evaluation of compounds of those chemical families known to have application la the psychochemical and "K" fields.^ Clinical work in the "natural toxic psychoses" carried out last year Indicates that* in general, the useful (reversible) phases of such psychoses are related to the presence of various chemical stressor materials In the circulation* These materials arise from faulty metabolic processes occasioned by the particular disease in question* Materials synthesised In the project are capable of reproducing the various clinical syndromes that are observed In the natural disease* 2. Knowledge of the nature of the Important Btressor compounds indicated above has allowed the design of an animal test which indicates __/ 'relative potency, mode of action, etc., of these materials without the C^vf^Tieceaaity of expensive and hazardous clinical testing in this area* a.. During the coming year as indicated in the attached proposal from a limited program of synthetic work and the attendant testing and screening will be carried out; but the major effort will . be related to studies directly concerned with- the production and control of the stress reaction In human beings* Tn line vith tbe _ requested reduction of effort in biochemical' research In TSS/CD, the funding of this project during the coming year has been reduced some 34$ over last year* - 7h** O 3 . also - serves as a general consultant to the Agency, provides services of a sensitive nature on an ad hoc basis, and serves as a cut-out in procurement problems. 4. The total cost of this project for a period of one year will not exceed 'f557200T€Q* Charges should be made against Allotment -2^2502=105001.- E2 II