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Bosnsracod t©i bUSliatRUfti. by authority ofs \374?8 date: June 1977 ~ E2 IMFDET; CIi BY 187473 26 January 1959 MEKG8AHDUM TOR: CDS RECORD _ - SUBJECT : Continuation of MEBlilRA, Subparojeet Ho. k$ Hli” 1. The scope of now engaged in by the _ under the direction of TSS/CD ulth the exception of functions specifically mentioned in connection with other MKOLTRA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years* These involve the synthesis and pharmacological and clinical evaluation of compounds of those chemical famlUea^mown to have application in the psythochemical and "X" fields. During the past year important progress has been made In the area related to stressor compounds and the relationship of these materials to the physiological pathways r through which both stress and the reaction to It are mediated In K > human beings. f( In our Agency frame of reference* the fast adaptive reaction (nervous control) is of more vital importance than the _ slower humoral reaction (pituitary-adrenal axis). Sines both of these pathways occur in the same individual, one of the major problems in doing research in this area has been the lade of knowledge of s techniques allowing one to distinguish between the various types of ’ J* observed phenomena. Progress made in this subproject on particular / stzessor agents and their relationships to knowwhumoral agents for the first tine permits the experimentor to make this distinction on a rational basis* As indicated in the attached proposal, this advantage will he pursued during the coming year with the following goals in minds (1) Development of materials & techniques for the production -of — maximum levels of physical and emotional stress In human beings. (2) Development of materials and techniques which produce a maximum attenuation of stress in human beings once It has been produced (3) Development of new and more reproducible indicators of stress than those now In use In the Agency* The emphasis in this will be { on those indicators which can be measured indirectly. (4) Elucidation of the significant properties of the negative phase of stress in order that psychological techniques may he worked out in other projects to exploit this phase of the human reaction to potent emotional stress. Domsraded to: CS!?F!DEH7!M by authority of; 137475 veto: June 1977 S3 Ii-FDEI ; CL BY 137475