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Vi'-7? Sorasraisa tot. COTEfmIBL t*7 aUi.verity of:' 187475 date: June 1977 ^2 13SBDEX; CL BY 137475^ 29 December 1959 MEMORANDUM FOR: THE RECORD SUBJECT Continuation of MKULTR A, Subproject No. 45 13 9 S • « > IS s\ S 3 2 5 a si 01 3 1. The scope of this subproject includes all those activities under the direction of TSSlfCD- with the exception of those cutout functions specifically mentioned in connection with other MKULTRA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years. These involve the synthesis and pharmacological and clinical evaluation of compounds of those chemical families known to have application in the psychochemical and "K" fields. During the past year important progress has been made in the area related to stressor compounds and the relationship of these materials to the physiological pathways through which both stress and the reaction to it are mediated in I ‘ . ' human beings, j As is indicated in the attached proposal, the work of the past year has progressed to the point where more definitive ~ experiments on the stress reaction can be carried out. Primarily this was brought about by the characterization of several new materials which produce stres-s reaction in humans and the applic&> tion of some new clinical methods of measuring the extent of the disturbance produced. During the next year proportionally more effort will be expended on the problem of the development of new , vi