◆ SpookStack

31 H»rcb 19^1 MEMORANDUM FOR: THE RECORD SUBJECT : Continuation of MKULTRA, Subproject Eo. k$ 1. The scope of this subproject Includes all those activities *T> now engaged In by under the direction of TSD/KB with the exception at those cutout functions specifically mentioned In connection with other MKULTRA subprojects. In general, the research effort under this subproject will continue along the lines laid down in previous years. These involve the synthesis and pharmacological and clinical evaluation of compounds of those chemical families known to have application In the psychochemical and "K" fields. During the past year important progress has been made In the ares related to stressor compounds and the relationship of these materials to the "physiological pathways through which both stress and the reaction to it are mediated in human beings. Also, several new and important animal screening techniques adapted to the study of materials which depress the general awareness at fttHmsi without producing any accompanying physical depression have been made available for work on "knockout" materials. In addition, some progress has been made in relating certain organic chemical structures to observed effects on animals. A considerable part of next year’s effort will be aimed at extending our ability to understand the structure activity relationships among these sleep-producing materials. E2 cutn 137473