◆ SpookStack

aa - fc? Request for’renewal of support for the ^?ojectj Trtvaatl Ration of tho~8 eed of Rivea Corymb09a (oloiuqul) . i Summary of work, November 1, 1955- September 25,1956* Physical examination of tho seed used in this work 'rove ale that two typos” have been under Investigation* Taxonomioally all the seed have boon palled Rlvea Cor^nbosa although one variety (the seed are the larger of the two _ varieties) originated in Mexico and one variety originated in Cuba, ©le literature on the subject of oieliuqul, as far as I can ascertain indicates. that its use as a psychic drun has been restricted to Mexico, This—data alone would lacks iexican ratory {small . n variety not Varieties, wo, a!30 physiological forenc e in the two iclusivo to bo such indicate the probability that the Cuba, some physiologically active component varie ty contains , Experimental work has been largely restricted to the C seed since only a very saaH amount has been available, Ihe cheaica.' desiejeed to compare the com ^ has indicated some difference^ in th tests on humans are indicative of a varieties, ; ihis work is m|h too inc more than speculation at tnmn time, in addition to th^^olK&^^^Slucose and hydro- ouinono as constituont^oKplolJKqui as reported^ in tho last progress report,yMNbystalline fractions have peon isolated which seem yJwither^ih be alkaloid ,or glycoside. Due to the small qoAntlty ofjdeed available tho amoun t of these crystallim frac>fohs is extremely small and ^ little more than quVill^t&v© tests have been made on thea* Bxperlmonp^l tecbjilquee-^especially in extraction and soparationyN&ave boon perfected which will be used to isolate purV^SEbneuts of the drug which, jU3 t te&ay, has become aHilablo In sufficient quantity to make the investigation profitable. Plana for fu|ilro Investigation ; L Kow that 50 pounds of the Cuban variety and 10 pounds of the ilexlcan variety are av<?llablo, the following linos of investigation will be actively pursued, ; • 1, Determine conclusively if there is ,« chemical difference in the two varieties ofseed, 2, Obtain as many "pure” components from each variety, using previously perfected techniques, as i 3 possible 3 , submit* for physiological testing each '’pure component, . , ... 4 , Subject each "uuro* component to chomlcaj. examination to doteralne tho typo of compound, whether it la a too'^rn conpoux/I ond £to choznlco 1 composition if it is a new compound.