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Approved For Release 2003 (00149 « GIA RDP96-00788R001300020001-6 ST-CS-O1-169-72. July 1972 © 8. (U) An interesting research report in 1968 appeared in the Soviet press which related biogenic amines with psychotropic drugs (211). The type of mental disturbance. produced .by psycho- pharmaceuticals was investigated in human volunteers. The volun- teers received a variety of compounds (not named) in 20-—150 mg doses. Psychic, disturbances were of two types: anxiety. depressive and deep depressive. The first group reported more phobias, . while the second ‘group exhibited genéral lassitude, and hypochon— driac symptoms. Adrenalin and noradrenalin were given by injection. DOPA and serotonin were also given. Creatine levels in the urine were determined after treatment. Other metabolites were detected chromatographically or by paper electrophoresis. Before treatment, group I patients excreted highet than normal levels of creatines, their metabolites and precursors, In the second group, excretion of catecholamines, precursors and metabolites was higher (up to 2 times) than in the controls.’ The administration of tranquilizers — (Librium) accompanied the reduction in excretion of abnormal = metabolites. ‘This study is important because it illustrates Soviet interest in not only biogenic amines, but also in the mode of action of psychotropic substances. Once the parameters are understood, then the development of highly sophisticated mood altering chemicals should follow. 9. (U) Of interest was the symposium on Mechanisms of Regulation of the Biogenic Amines Level in the Tissues held in Lodz, Poland in August. of 1971. No data is available but the abstracts of the papers is to be published in Acta Medica Polonica in April of 1972. The main aim of the symposium was for the comparison of data on the mechanisms of regulation of the biogenic amines level in the tissues with special emphasis on the role of enzymes respon- ~ sible for synthesis, catalysis, and storage of amines. 10. (U) The relationship of psychoactive drugs to amine activity is shown in Table IV below. TABLE IV Relation of Psychoactive Drugs to Amine Activity (209) A. : Drugs which impair amine synaptic activity ol. .Tranquilizers a. Inhibitors of vesicle binding: rauwolfia alkaloids—- e.g. reserpine b. Blockers of receptor sites: phenothiazines, butyrophenones—-e.g. chlorpromazine and halo- peridol 73 UNCLASSIFIED Approved For Release 2003/09/10 : CIA-RDP96-00788R001300020001-6